As of January - April 2026, we have multiple Ph.D. positions available in our group starting in the academic year 2026/2027.

As part of new grant projects, we are looking for candidates interested in studying tumor biology of lymphomas who want to learn a wide range of modern methods, the basics of bioinformatic data processing, apply for their own grants, and publish in international journals. We offer topics in both basic and preclinical research.

Offered topics:

Molecular mechanisms of B-cell receptor signaling in EZB diffuse large B-cell lymphoma

- The main focus of the project is to determine how somatic genetic alterations affect B-cell receptor signaling in the most common type of lymphoma. Based on literature and our preliminary data, it is assumed that these alterations influence the dynamics of cortical actin and related B-cell receptor signaling.

Multicombinatorial vertical inhibition of the PI3K/AKT signaling pathway in B-cell lymphomas

- The proposed dissertation project focuses on basic research into the molecular mechanisms of multicombination vertical inhibition of the PI3K/AKT signaling pathway in B-cell lymphomas. The project builds on previous results from our research group, which showed that simultaneous inhibition of multiple regulatory levels of the PI3K/AKT pathway leads to more stable signaling inhibition than inhibiting individual members of the pathway.

Treatment of lymphomas using organoid models without the use of chemotherapeutics

- The proposed project aims to develop innovative chemo-free therapeutic strategies through organoid in vitro models that faithfully mimic the complex interactions between tumor cells and their microenvironment. These interactions cannot be explored in detail in conventional 2D cell models, which significantly limits the current understanding of the molecular mechanisms of lymphomagenesis and therapeutic resistance.

Development of new approaches to assess the cellular toxicity of nanomaterials and nano-bio interactions with a focus on regulated forms of cell death

- Nanotechnology is a rapidly developing field with potential in cancer treatment. The aim of the project is to develop new approaches to assess the toxicity of nanomaterials and nano-bio interactions based on identifying their ability to induce various forms of regulated cell death (apoptosis, erythrocytosis, necrosis, ferroposis, pyroposis, etc.) with subsequent testing of the therapeutic applicability of the most promising nanomaterials.

We offer work in a friendly environment within a dynamic group with established international cooperation, operating in a modern scientific center with first-class research facilities. As part of your studies, you will have the opportunity to complete a 6-12 month internship abroad.

Fully funded positions are available with an expected start date in the 2026/2027 academic year.

If you are interested, please send your CV and a short summary of why you would be interested in working in our group to the following email address: ondrej.havranek@lf1.cuni.cz

If you are interested in bachelor's or master's thesis or to join our group as a postdoctoral fellow, let me know also at ondrej.havranek@lf1.cuni.cz