A new Ph.D. student
10/2024
We are happy that a new Ph.D., Mgr. Karin Ravaszova, just joined our group. She will be working on specifics of BCR signaling in lymphoma and with Dr. Huskova on her project focused on AID activity in solid cancers and associate histone mutations.
NOVEL CONCEPT - Vertical targeting of the PI3K/AKT pathway
9/2024
Traditional cancer therapeutic combinations focus on targeting different signaling pathways and/or cellular processes at once. However, single agent-based targeting of a signaling pathway might not be sufficient for its inhibition. We have shown this for the PI3K/AKT pathway, where lymphoma cells normalized AKT activity within 24 hours even in the presence of a specific pathway inhibitors. To overcome this issue, we have developed a new approach that we called “vertical” signaling inhibition and showed that targeting PI3K/AKT pathway at multiple levels (multiple members) at the same time is synergistic, effective, and tolerated in vivo. Our results were just published in D1 journal!
Kupcova K, Senavova J, Jura F, Herman V, Rajmonova A, Pacheco-Blanco M, Chrbolkova T, Hamova I, Davis RE, Havranek O. Vertical targeting of the PI3K/AKT pathway at multiple points is synergistic and effective for non-Hodgkin lymphoma. Exp Hematol Oncol. 2024 Nov 1;13(1):108. (2023 IF 9.4, D1) Full-text link
Impact of PIK3CA gain and PTEN loss in mantle cell lymphoma
8/2024
Within a collaborative project with prof. Klener, this study from Havranek laboratory described some of the key consequences associated with phosphatidylinositol 3-kinase / protein kinase B (PI3K/AKT) signaling pathway oncogenic activation. PI3K/AKT pathway is one of central cellular pathways which is frequently altered by PIK3CA amplifications and PTEN deletions in lymphomas. We have shown that in mantel cell lymphoma, its oncogenic activation associates with lower dependence on upstream activation, better metabolic and hypoxic adaptation, and targeted therapy resistance. All features of more aggressive tumor behavior with possible critical therapeutic consequences.
Bettazova N, Senavova J, Kupcova K, Sovilj D, Rajmonova A, Andera L, Svobodova K, Berkova A, Zemanova Z, Daumova L, Herman V, Dolnikova A, Davis RE, Trneny M, Klener P, Havranek O. Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies. Blood Adv. 2024 Oct 22;8(20):5279-5289 (2023 IF 7.4, Q1) Full-text link
Viktoriia defends her master’s thesis!
4.6.2024
Viktoriia successfully defended her master's thesis with the best grade (vyborne)! We are all very happy for her!
Adriana received GAUK grant!
25.3.2024
Adriana received GAUK grant to study genetic changes in T-cell lymphoma.
Congratulations!
A new laboratory member
1.3.2024
We are happy that a new postdoctoral fellow, Dr. Huskova, just joined our laboratory. Moreover, she received GACR incoming fellowship grant!
Filip joined MD Anderson Cancer Center for 12 months
15.2.2024
Our Ph.D. student Filip just joined group of Michael Green at the MD Anderson Cancer Center, Houston, Texas, U.S.A. for 12 moth fellowship sponsored by the Charles University mobility grant.
An outstanding opportunity to work at the best cancer research institut!
Anežka joined Josep Carreras Leukaemia Research Institute for 6 months
1.7.2023
Our Ph.D. student Anežka (second from left) just came back from her 6 months stay in the group of Gael Roue at the Josep Carreras Leukemia Research Institute in Spain. Nice opportunity to experience best lymphoma translational research and learn the chicken choriallantoic membrane tumor model.
Ondrej succesfully defended Bc. thesis
29.5.2023
Our Bc. student, Ondrej Hostas, just succesfully defended his Bc. thesis with the best grade (vyborne)!
CONGRATULATIONS!
Václav very successful at student’s conference
23.5.2023
Success at the 2023 students conference of the First School of Medicine, Charles University
Vaclav was awarded second place in the postgraduate poster section!
Congratualtions!
Anezka and Filip received GAUK grants
14.3.2023
Both submitted GAUK grants from our Ph.D. students Anezka and Filip were selected for funding! Big success, congratulations!
Anton received support from EHA
1.3.2022
Anton just received one year funding form the European Hematology Association - Ukraine Bridge Program.
We are very happy about it and big thank to EHA!
Vaclav spend 3 months in the laboratory of prof. Chapuy
1.12.2022
Within our ongoing collaboration, our Ph.D. student, Vaclav, just came back from three moths fellowship in the laboratory of Bjoern Chapuy (Department of Hematology, Oncology and Tumorimmunology Charité Universitätsmedizin Berlin, Germany), focusing mainly on alternative AKT activation in lymphomas. A very good opportunity to visit a top lymphoma research lab.
New member of our laboratory
1.11.2022
We are happy that assoc prof. AntonTkchanko, MD, PhD from Kharkiv National Medical University just joined our lab for 5 moths stay!
Two our PhD students selected for MD/PhD program
10.9.2022
Our second year PhD students, Drs. Ondeckova and Senavova, were selected for prestigious MD/PhD program of General University Hospital in Prague and First Faculty of Medicine (Charles University). Congratulations!
Victoriia succesfully defended Bc. thesis
2.9.2022
Our Bc. student, Victoriia Kulinich, just succesfully defended her Bc. thesis with the best grade (vyborne)!
CONGRATULATIONS!
Our review on the current status of circulating tumor DNA in Hodgkin Lymphoma just published.
8.9.2022
Working on the project of circulating tumor DNA in lymphomas, we reviewed all available literature to create the most relevant study design. Having detailed notes on these studies, we decided to summarize all the comprehensive information in a review article to make it readily available to the scientific community.
FRET-based AKT activity biosnesor article accepted
25.6.2021
We are happy that our article summarizing the upgrades of FRET-based AKT activity reporter, including newly developed techniques of FRET detection using conventional cytometry as well as spectral cytometry got accepted for publication! We believe that this makes the use of such biosensors and FRET detection much easier and generally accessible.
Václav and Tereza were very successful at student’s conference
16.6.2021
Both abstracts submitted for the 2021 students conference of the First School of Medicine, Charles University, by our PhD students Tereza Chrbolková and Václav Heřman were selected for oral presentation!
Moreover, Václav was awarded a first price in the oral section of PhD students!
Congratulations!
Kristýna joined ETH Zurrich for six months
1.3.2021
We are very happy that Kristýna Kupcová from our lab got the opportunity to join the laboratory of prof. Zamboni at ETH Zurich for six months, one of the best metabolomics laboratories. This is an outstanding opportunity. We are looking forward to our metabolomics studies and collaborations.
Patryk Gorniak joined our lab
1.2.2021
Patryk Gorniak, Ph.D. just joined our lab for nine moths stay to work on a collaborative project between our laboratory and the laboratory of prof. Przemyslaw Juszczynski (Institute of Hematology and Transfusion Medicine, Warsaw, Poland) on BCR endocytosis using our genetic models of BCR signaling. Very interesting project.
